I take Seroquel XR to help me sleep. I've taken both the regular and extended release (XR) versions, sometimes both together. The immediate release one was good for helping me fall asleep and the extended release helps keep me asleep. Hence, withdrawal from Seroquel can be especially challenging, perhaps even more so than coming off benzodiazepine drugs. When Seroquel is reduced, the dopamine expression is now potentially greatly enhanced, and the symptoms of mania may also return, bringing in an increased sense of reward. Quetiapine, sold under the trade name Seroquel among others, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder. The timeline along which the symptoms of Seroquel withdrawal will develop will also vary significantly from person to person based on the same issues that Seroquel (Quetiapine) is a medication commonly prescribed to patients with schizophrenia or bipolar disorder. If not properly discontinued, Seroquel can cause very serious withdrawal symptoms. Your physician may decide how the doses of Seroquel are to be gradually lowered, to wean you off the drug slowly and to avoid withdrawal symptoms and relapse, although this may not be necessary in all situations. Seroquel Withdrawal Symptoms: List of Possibilities Below are a list of common symptoms that have been reported during Seroquel withdrawal. Keep these symptoms in mind when you come off of the medication so that you know what to expect. Headaches, dizziness and irritability accompany the abrupt withdrawal of Seroquel. Neurological brain chemicals normally can work together with antipsychotic and antidepressant medications, easing symptoms of mental illness. Seroquel Withdrawal Although Seroquel is not likely to be abused, withdrawal symptoms are possible as the brain adjusts to a reduction in the medication. Symptoms can include nausea and vomiting, insomnia, and symptoms of bipolar disorder or schizophrenia. Best Answer: Seroquel withdrawal symptoms are not known to be particularly unfavorable for people who discontinue use of this atypical antipsychotic prescription drug. Seroquel (quetiapine) was approved in 1997 to treat the adverse psychological symptoms of schizophrenia including delusions, hallucinations.